Holistic drug design for multiparameter optimization in modern small molecule drug discovery
نویسندگان
چکیده
منابع مشابه
Advances in multiparameter optimization methods for de novo drug design.
INTRODUCTION A high-quality drug must achieve a balance of physicochemical and absorption, distribution, metabolism and elimination properties, safety and potency against its therapeutic target(s). Multiparameter optimization (MPO) methods guide the simultaneous optimization of multiple factors to quickly target compounds with the highest chance of downstream success. MPO can be combined with '...
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ژورنال
عنوان ژورنال: Bioorganic & Medicinal Chemistry Letters
سال: 2021
ISSN: 0960-894X
DOI: 10.1016/j.bmcl.2021.128003